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Antiviral Therapy

Tripeptide inhibitors staunch the replication of subgenomic hepatitis C RNA

Published in Hepatitis Weekly, February 28th, 2005

Tripeptide inhibitors staunch the replication of subgenomic hepatitis C RNA.

"The inadequate efficacy and tolerability of current therapies for the infectious liver disease caused by the hepatitis C virus have warranted significant efforts in the development of new therapeutics. We have previously reported competitive peptide inhibitors of the NS3 serine protease based on the N-terminal cleavage products of peptide substrates," scientists in Canada report.

"A detailed study of the interactions of these substrate-based inhibitors with the different subsites of the serine protease active site led to the discovery of novel residues that increased the...

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