Virology
Hepatitis C NS3 interaction with immunoproteasome domain allows immune evasion
Published in Hepatitis Weekly, February 28th, 2005
According to a study from Singapore, "NS3, a non-structural protein of the HCV (hepatitis C virus), contains a protease and a helicase domain and plays essential roles in the processing of the viral polyprotein, viral RNA replication and translation."
"LMP7 (low-molecular-mass protein 7), a component of the immunoproteasome, was identified as an NS3-binding protein from yeast two-hybrid screens, and this interaction was confirmed by in vitro binding and co-immunoprecipitation analysis. The minimal domain of interaction was defined to be between the pro-sequence region of...
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Source: Hepatitis Weekly (2005-02-28)
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