Stem Cell Research

PU.1 necessary for maintenance of fetal liver hematopoietic stem cells

Published in Hepatitis Weekly, March 7th, 2005

The PU.1 transcription factor is necessary for the maintenance of fetal liver hematopoietic stem cells.

"PU.1 is a member of the ETS family of transcription factors and is required for the development of multiple hematopoietic lineages. PU.1-/- mice die from hematopoietic failure at about embryonic day 18.5 (e18.5) and show a complete absence of B cells, mature T cells, and macrophages.

"This phenotype suggests that PU.1 may function at the level of the hematopoietic stem cell (HSC) or a multilineage progenitor," investigators in the United States report.

"To investigate the role of PU.1 in the regulation of HSCs," wrote H.G. Kim...

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Source: Hepatitis Weekly (2005-03-07)

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