Diagnostics

HPLC detects depression-linked markers in hepatitis C patients on interferon

Published in Hepatitis Weekly, March 14th, 2005

HPLC detects depression-linked markers in hepatitis C patients on interferon.

According to recent research from France, "tryptophan metabolism is disturbed in mental depression, and the induction of indoleamine 2,3-dioxygenase increases kynurenine production."

"In order to determine this disturbance in patients with chronic hepatitis C and receiving interferon-based immunotherapy, a new and specific HPLC protocol was elaborated," wrote J. Vignau and colleagues, University of Lille 2, Faculty Pharmacy.

"For tryptophan, the assay was linear from 6.25 to 100 mcmol L^-1, and the limits of detection (LOD) and quantitation...

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Source: Hepatitis Weekly (2005-03-14)

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