Hepatology
Rho-kinase and MLCK regulate sinusoidal endothelial fenestrae organization
Published in Hepatitis Weekly, March 21st, 2005
"The presence of actin filaments in the neighborhood" of SEF "indicates that the cytoskeleton of sinusoidal endothelial cells (SEC) plays an important role in the modulation of SEF," hepatologists in Japan explained.
In their study, H. Yokomori and coauthors at the Kitasato Medical Center Hospital "examined the roles of Rho-kinase and myosin light chain kinase (MLCK) in the organization of SEF."
"Cultured SEC were treated with MLCK inhibitor (ML-7) and Rho-kinase inhibitor (Y-27632)," and "SEF morphology was observed by scanning electron microscopy,"...
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Source: Hepatitis Weekly (2005-03-21)
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