Drug Resistance

Genotypic monitoring helps manage patients with drug-resistant hepatitis B

Published in Hepatitis Weekly, March 28th, 2005

Genotypic monitoring helps manage patients with drug-resistant hepatitis B.

According to researchers in the Peoples Republic of China, "we have investigated the characteristics of lamivudine-resistant strains in patients with chronic hepatitis B in Guangdong, China, where the predominant genotypes are B and C. Two hundred forty-seven patients treated with lamivudine in Nanfang Hospital were followed-up."

"Patients with hepatitis B e antigen (HBeAg) positive and hepatitis B virus (HBV)-DNA levels over 7.5 x 10⁶ copies/ml at baseline had a shorter time to the selection of YMDD mutant (p=0.02 and 0.00, respectively)," said J. Sun and...

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Source: Hepatitis Weekly (2005-03-28)

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