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Oncology

Environmental factors modify genetic susceptibility to primary liver cancer

Published in Hepatitis Weekly, April 18th, 2005

Environmental factors modify genetic susceptibility to primary liver cancer.

According to a study from the United States, "high rates of hepatocellular carcinoma (HCC) in The Gambia, West Africa, are primarily due to a high prevalence of chronic hepatitis B virus infection and heavy aflatoxin exposure via groundnut consumption. We investigated genetic polymorphisms in carcinogen-metabolizing (GSTM1, GSTT1, HYL1*2) and DNA repair (XRCC1) enzymes in a hospital-based case-control study."

"Incident HCC cases (n=216) were compared with frequency-matched controls (n=408) with no clinically apparent liver disease," wrote G.D. Kirk and colleagues, U.S....

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