Mutagenesis
Keratin mutations leave liver cells open to oxidative injury
Published in Hepatitis Weekly, April 25th, 2005
According to a study from the United States, "mutation of the cytoskeletal intermediate filament proteins keratin 8 and keratin 18 (K8/K18) is associated with cirrhosis in humans, whereas transgenic mice that overexpress K18 Arg89-->Cys (R89C) have significant predisposition to liver injury. To study the mechanism of keratin-associated predisposition to liver injury, we used mouse microarrays to examine genetic changes associated with hepatocyte keratin mutation and assessed the consequences of such changes."
"Liver gene expression was compared in R89C versus nontransgenic or wild-type...
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Source: Hepatitis Weekly (2005-04-25)
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