Virology
The effects of hepatitis C alternate reading frame and core protein overlap
Published in Hepatitis Weekly, April 25th, 2005
"The hepatitis C virus (HCV) has an alternate reading frame (ARF) that overlaps the core protein gene. The overlapping reading frame distinguishes HCV from all of its known viral relatives, with the possible exception of GB virus B (GBV-B). The ARF is expressed during natural HCV infections and stimulates specific immune responses," scientists writing in the journal Seminars in Liver Disease report.
"Like several essential genes in other viruses (e.g., the human immunodeficiency virus polymerase) the ARF lacks an in-frame AUG start codon, suggesting that its...
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Source: Hepatitis Weekly (2005-04-25)
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