Virology
Vesicular stomatitis virus pseudotypes help analyze early hepatitis C infection
Published in Hepatitis Weekly, April 25th, 2005
"Hepatitis C virus (HCV) causes chronic hepatitis, liver cirrhosis and hepatocellular carcinoma in addition to acute hepatitis. The HCV genome encodes two envelope glycoproteins, E1 and E2. To investigate the role of E1 and E2 in HCV infection, we used a recombinant vesicular stomatitis virus (VSV), VSVDeltaG*, harboring the green fluorescent protein gene instead of the VSV G envelope protein gene," scientists in Japan report.
"It was complemented with the native form of E1 and E2, or E1 or E2 alone, to make HCV pseudotypes VSVDeltaG*(HCV), VSVDeltaG*(E1), and...
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Source: Hepatitis Weekly (2005-04-25)
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