Chronic Hepatitis B
Peripheral cytotoxic T lymphocytes wane in response to hepatitis B infection
Published in Hepatitis Weekly, May 16th, 2005
"The distribution and dynamics of the cytotoxic T lymphocyte (CTL) response to hepatitis B surface antigen (HBsAg) were studied in mice after intramuscular DNA immunization and after hepatic infection by a recombinant adenovirus that expresses the hepatitis B virus genome (Ad-HBV)," scientists in the United States report.
"CTLs specific for HBsAg accumulate preferentially in the spleen after DNA immunization but are primarily intrahepatic after Ad-HBV infection. The secondary CTL response to Ad-HBV in DNA-primed mice is characterized by rapid depletion of effector CTLs from...
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Source: Hepatitis Weekly (2005-05-16)
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