Enzymology

Hepatitis B virus X protein activates genes involved in cell migration

Published in Hepatitis Weekly, June 6th, 2005

Hepatitis B virus X protein activates genes involved in cell migration.

According to published research from Taiwan, "hepatitis B virus (HBV), a major causative agent of hepatocellular carcinoma (HCC), encodes an oncogenic X protein (HBx) that transcriptionally activates multiple viral and cellular promoters. How this regulation influences HCC is unclear."

"Global gene expression in HBx-expressing and non-expressing hepatoma cells was analyzed using cDNA microarrays," wrote F.L. Yu and colleagues, Tzu Chi University, Department of Life Sciences.

The research indicates that "genes that were markedly up- or down-regulated in the...

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Source: Hepatitis Weekly (2005-06-06)

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