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Gastroenterology

Osteoactivin levels escalate in livers with acute injury

Published in Hepatitis Weekly, June 6th, 2005

Osteoactivin levels escalate in livers with acute injury.

According to recent research from Germany, "the transmembrane glycoprotein osteoactivin is expressed in osteoblasts, dendritic cells, and tumor cells. It is suggested to influence osteoblast maturation, cell adhesion, and migration. We studied osteoactivin expression within the liver."

"Expression of osteoactivin was analyzed by reverse transcription-polymerase chain reaction (RT-PCR), Northern blotting, in situ hybridization (ISH) and immunohistochemistry (IHC) comparing normal and acutely injured rat liver [induced by carbon tetrachloride (CCl4) administration], liver cell populations, and...

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