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Hepatitis B Virus

Prophylaxis stalls viral recurrence in transplanted carriers of YMDD mutants

Published in Hepatitis Weekly, June 20th, 2005

Prophylaxis stalls viral recurrence in transplanted carriers of YMDD mutants.

According to recent research from Italy, "the combination of lamivudine and hepatitis B immunoglobulin (HBIG) reduces the risk of hepatitis B virus (HBV) recurrence after liver transplantation (LT). However, the efficacy of this strategy and the need for combined therapy with adefovir dipivoxil (ADV) in patients who select lamivudine-resistant strains (YMDD) before surgery is still unknown."

"Twenty-two patients treated with lamivudine (LAM) who underwent LT after YMDD-mutant selection were studied," wrote A. Marzano and colleagues, Osped San Giovanni Battista...

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