Chronic Liver Disease
Auto-antibodies are unsuitable for diagnosing cholestatic liver diseases
Published in Hepatitis Weekly, July 25th, 2005
"Auto-antibodies are an integral part of the diagnostic armentarium in chronic cholestatic liver disorders, such as primary sclerosing cholangitis (PSC), primary biliary cirrhosis (PBC), auto-immune cholangitis, or overlap syndromes among these disorders. However, care should be taken not to overestimate the diagnostic specificity," scientists in Germany report.
"Auto-antibodies to mitochondrial antigens (AMAs) with reactivity to the E2 subunit of the pyruvate dehydrogenase complex represent the hallmark antibody for the diagnosis of PBC, whereas antinuclear antibodies (ANAs)...
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Source: Hepatitis Weekly (2005-07-25)
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