Virology
Hepatitis B virus genotype drives interferon efficacy
Published in Hepatitis Weekly, August 8th, 2005
According to recent research from Germany, "current interferon alfa (IFN) treatment of chronic hepatitis B has limited efficacy. The role of hepatitis B virus (HBV) genotypes for response to IFN was investigated."
"HBV genotype was determined by direct sequencing of the HBV X gene in 165 consecutive patients with chronic replicative hepatitis B treated with standard IFN. HBV genotype A or D was found in 144 cases. Sustained response (6 months after treatment) to standard IFN therapy was higher in HBV genotype A compared with HBV genotype D infected patients (49% vs. 26%; p<0.005)," reported A....
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Source: Hepatitis Weekly (2005-08-08)
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