Oncogenesis
Hepatitis C may trigger B-cell disorders through CD81 and E2 interaction
Published in Hepatitis Weekly, August 15th, 2005
According to a study from the United States, "hepatitis C virus (HCV) is one of the leading causes of chronic liver diseases and B-lymphocyte proliferative disorders, including mixed cryoglobulinemia and B-cell lymphoma. It has been suggested that HCV infects human cells through the interaction of its envelope glycoprotein E2 with a tetraspanin molecule CD81, the putative viral receptor."
"Here, we show that the engagement of B cells by purified E2 induced double-strand DNA breaks specifically in the variable region of immunoglobulin (V-H) gene focus, leading to hypermutation...
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Source: Hepatitis Weekly (2005-08-15)
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