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Chronic Liver Disease

Apparent diffusion coefficient measurements help stage liver fibrosis

Published in Hepatitis Weekly, August 22nd, 2005

Apparent diffusion coefficient measurements help stage liver fibrosis.

Scientists in Japan conducted a study "to evaluate the use of apparent diffusion coefficient (ADC) measurements based on diffusion-weighted MRI (DWI) to assess stage of liver disease. A total of 31 patients who underwent both a liver biopsy and DWI and 132 patients who only underwent DWI were enrolled. Biopsy specimens were scored for fibrosis and necroinflammation according to the Knodell histology activity index (HAI)."

"The 31 patients consisted of 21 patients with chronic hepatitis and 10 with cirrhosis (Child-Pugh stage A in nine and stage B in one), and the 132 patients...

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