Allergy & Immunology
Hepatic CD8+ T-lymphocyte response is required for clearing hepatitis B
Published in Hepatitis Weekly, August 29th, 2005
"To determine which immune cells contribute to HBV-clearance during antiviral therapy, we performed a longitudinal analysis of intrahepatic immune cells during interferon-alpha therapy of chronic HBV-patients using the FNAB technique. Twenty chronic HBeAg+-patients were treated with pegylated alpha-interferon combined with lamivudine or placebo for 52 weeks. FNAB and blood specimens were obtained at week 0, 2, 8 and 52," according to scientists in The Netherlands.
"CD4+-and CD8+ T-lymphocytes, CD56+ cells, IFN gamma and granzyme B (GrB) were immunocytochemically quantified. The...
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Source: Hepatitis Weekly (2005-08-29)
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