Hepatitis B Vaccine

HBV vaccine questionable in patients receiving lamividine post liver transplant

Published in Hepatitis Weekly, September 5th, 2005

Recombinant HBV vaccine has questionable value in patients receiving lamividine post liver transplant.

"Lamivudine prophylaxis against hepatitis B virus (HBV) reinfection after liver transplantation is associated with recurrence due to escape mutants. Fifty-two patients on lamivudine prophylaxis at a median of 412 days (median, 370-2040 days) after transplantation for chronic HBV-related liver disease received two courses of an accelerated schedule of double-dose recombinant HBV vaccine. Before vaccination, all patients were seronegative for HBsAg, anti-HBs and HBV DNA (by qPCR)," reported C.M. Lo and associates at the University of Hong Kong in a recent issue of the...

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Source: Hepatitis Weekly (2005-09-05)

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