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Genetics

Expression profile analysis could help evaluate potential hepatotoxicant

Published in Hepatitis Weekly, October 17th, 2005

Relationship between hepatic gene expression profiles and hepatotoxicity could be helpful in drug discovery.

According to recent research from Japan, "In the field of gene expression analysis, DNA microarray technology has a major impact on many different areas including toxicogenomics, such as in predicting the adverse effects of new drug candidates and improving the process of risk assessment and safety evaluation. In this study, we investigated whether there is relationship between the hepatotoxic phenotypes and gene expression profiles of hepatotoxic chemicals measured by DNA microarray analyses."

"Sprague-Dawley rats (6 weeks old) were...

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