Hepatitis C Therapy
Interleukin-10 receptor blockade may augment therapy targeting hepatitis C
Published in Hepatitis Weekly, November 7th, 2005
"Chronic hepatitis C virus (HCV) infection is associated with weak CD4+ T-helper type I reactivity and enhanced IL-10 production to HCV antigens. Here we demonstrate in vitro that monoclonal antibody-induced blockade of IL-10 receptor (IL-10R) generates a favorable balance of CD4+ T-cell responses to HCV," investigators in England report.
"The addition of anti-IL-10R to mononuclear cells leads to a dose-dependent increase of T-cell proliferative response to HCV core, non-structural proteins 3 and 4," according to E.I. Rigopoulou and colleagues, University College...
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Source: Hepatitis Weekly (2005-11-07)
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