Hepatitis C Therapy
Cyclic molecule targeting hepatitis C virus IRES RNA domain blocks translation
Published in Hepatitis Weekly, November 14th, 2005
According to recent research published in the journal Bioorganic & Medicinal Chemistry, "a cyclic molecule 1 constituted by a hepta-peptide nucleic acid sequence complementary to the apical loop of domain IV of HCV IRES RNA has been prepared via a 'mixed' liquid-phase strategy, which relies on easily available protected PNA and poly(2-aminoethylglycinamide) building blocks."
"This compound 1 has been elaborated to mimic 'loop-loop' interactions. For comparison, its linear analog has also been investigated," wrote S.A. Caldarelli...
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Source: Hepatitis Weekly (2005-11-14)
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