Hepatitis B Virus

E-cadherin expression represses via activation of DNA methyltransferase 1

Published in Hepatitis Weekly, November 28th, 2005

According to recently published research from South Korea, hepatitis B virus (HBV) X protein represses E-cadherin expression via activation of DNA methyltransferase 1.

"E-cadherin is a key cell adhesion molecule implicated as a tumor suppressor, which is frequently altered in hepatocellular carcinoma, especially in HBV-related tumors."

"Here," wrote J.O. Lee and colleagues, Pusan National University, "we report that HBV X protein (HBx) represses E-cadherin expression at the transcription level."

"Based on the differential effects of HBx natural variants, we determined that Lys-130 in the transactivation domain of HBx is critical...

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Source: Hepatitis Weekly (2005-11-28)

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