Hepatitis C Virus
Hepatitis C virus mutations confer resistance to RNA-dependent RNA polymerase inhibitor
Published in Hepatitis Weekly, November 28th, 2005
"Compounds A-782759 (an N-1-aza-4-hydroxyquinolone benzothiadiazine) and BILN-2061 are specific anti-HCV agents that inhibit the RNA-dependent RNA polymerase and the NS3 serine protease, respectively. Both compounds display potent activity against HCV replicons in tissue culture."
"In order to characterize the development of resistance to these anti-HCV agents," wrote H.M. Mo and colleagues, Abbott Laboratories, "HCV subgenomic...
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Source: Hepatitis Weekly (2005-11-28)
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