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Infectious Diseases

Soluble hepatitis C core protein induces interleukin expression in pulmonary fibroblasts

Published in Hepatitis Weekly, November 28th, 2005

Recent research from the United States has chronicled the induction of interleukin-8 (IL-8) expression in pulmonary fibroblasts by soluble hepatitis C core protein.

"Recent studies suggest that HCV infection is associated with progressive declines in pulmonary function in patients with underlying pulmonary diseases such as asthma and chronic obstructive pulmonary disease. Few molecular studies have addressed the inflammatory aspects of HCV-associated pulmonary disease."

"Because IL-8 plays a fundamental role in reactive airway diseases, we examined IL-8 signaling in normal human lung fibroblasts (NHLF) in response to the HCV nucleocapsid core...

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