Hepatocellular Carcinoma

Frizzled receptor has an oncogenic role in hepatocellular carcinoma

Published in Hepatitis Weekly, December 26th, 2005

Recent research from the United States has contributed to cancer therapy by chronicling the oncogenic role of the frizzled-7/beta-catenin pathway in hepatocellular carcinoma (HCC).

"The molecular mechanisms of hepatocarcinogenesis remain largely unknown. Previous studies suggest that activation of the Wnt/beta-catenin pathway is important during hepatocyte transformation but the role of Frizzled receptor (FZD) in this process has not been defined."

"Here we investigate activation of this pathway by FZD using transgenic HCC murine models," wrote P. Merle and colleagues, Brown University.

"We employed single (c-myc, SV40-Tag) and...

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Source: Hepatitis Weekly (2005-12-26)

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