Hepatitis C Virus
Hepatitis C virus core protein inhibits suppressor of cytokine signaling-1 gene expression
Published in Hepatitis Weekly, December 26th, 2005
"SOCS-1, a negative feedback regulator of cytokine signaling pathway, also has a tumor suppressor activity, the silencing of its gene by hypermethylation is suggested to contribute to hepatocarcinogenesis."
H. Miyoshi and colleagues, University of Tokyo, wrote, "We studied the effect of the core protein of HCV on the expression of SOCS-1 gene."
"HCV core gene transgenic mice, which develop hepatocellular carcinoma late in life, HepG2 cells expressing the core...
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Source: Hepatitis Weekly (2005-12-26)
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