Published in Hepatitis Weekly, December 26th, 2005
According to a study from the United States, "A pulsating flow of medium was used to alleviate diffusion and transport limitations in a hollow fiber bioreactor containing a human hepatoblastoma cell line. The strategy is easy to implement but effective."
"The pulsating flow is introduced by a solenoid pinch valve at the outlet of the bioreactor and regulated by a timing circuit," D.T. Nguyen and colleagues at the University of California, San Diego wrote.
"In a permeability test," said the authors, "the system with pulsating flow had much less membrane...
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