Genetics & Genomics

Mutations in mouse hepatitis virus protein binding element influence RNA replication

Published in Hepatitis Weekly, January 9th, 2006

A recent study from the United States has reported on the effect of mutations in the mouse hepatitis virus (MHV) 3'(+)42 protein binding element on RNA replication.

"The MHV genome's 3' untranslated region contains cis-acting sequences necessary for replication. Studies of MHV and other coronaviruses have indicated a role for RNA secondary and tertiary elements in replication," wrote R.F. Johnson and colleagues, Texas A&M University.

"Previous work in our laboratory has identified four proteins which form ribonucleoprotein complexes with the 3'-terminal 42 nucleotides [3'(+)42] of the MHV genome. Defective interfering (DI) RNA replication assays have...

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Source: Hepatitis Weekly (2006-01-09)

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