Autoimmune Diseases

Cytotoxic antigen induces autoimmune hypophysitis in cancer patients

Published in Hepatitis Weekly, January 9th, 2006

According to research published from the United States, cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer.

"CTLA-4 is an immunoregulatory molecule expressed by activated T cells and resting CD4+ CD25+ T cells. In patients with advanced melanoma, our group reported that administration of anti-CTLA-4 antibody mediated objective cancer regression in 13% of patients."

"This study also established that the blockade of CTLA-4 was associated with grade III/IV autoimmune manifestations that included dermatitis, enterocolitis, hepatitis, uveitis, and a single...

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Source: Hepatitis Weekly (2006-01-09)

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