Liver Injury

TLR ligand attenuates liver injury by down-regulating macrophage TLR expression

Published in Hepatitis Weekly, January 23rd, 2006

According to recent research from the People's Republic of China, toll-like receptor (TLR)3 ligand attenuates lipopolysaccharide (LPS)-induced liver injury by down-regulation of TLR4 expression on macrophages.

"This study demonstrates that pretreatment with polyinosinicpolycytidylic acid (poly I:C) significantly decreased the mortality and liver injury caused by injection of LPS in the presence of D-galactosamine (D-GaIN) in C57BL/6 mice. Depletion of natural killer, natural killer T, and T cells did not change the protective effect of poly I:C on LPS/D-GaIN-induced liver injury in vivo."

"However," wrote W. Jiang and colleagues, University of...

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Source: Hepatitis Weekly (2006-01-23)

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