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Hepatitis B Virus

Naive antibody phage library contains HBV neutralizing antibody fragments

Published in Hepatitis Weekly, February 6th, 2006

According to a study from South Korea, a large naive antibody phage library contains hepatitis B virus (HBV) neutralizing antibody fragments.

S.G. Park and colleagues, Seoul National University, wrote, "We report the construction of a large nonimmunized human phage antibody library in single-chain variable region fragment (scFv) format, which allowed the selection of antibodies that neutralize HBV in vitro."

"We generated 1.1 x 1010 independent scFv clones using the cDNA of functional variable (V) gene segments of heavy and light chains purified from the peripheral blood mononuclear cells of 50 nonimmunized human donors."

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