Published in Hepatitis Weekly, February 6th, 2006
"HCV is a global epidemic manifested mainly by chronic infection. One strategy that HCV employs to establish chronic infection is to use the viral Ser protease NS3/4A to cleave some unknown cellular targets involved in innate immunity."
"Here we show that the target of NS3/4A is the mitochondrial antiviral signaling protein, MAVS, that activates NF-kappa B and IFN regulatory factor 3 to induce type-1 interferons," wrote X.D. Li and colleagues, University of Texas,...
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