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Biomedical Engineering

Mild hypothermia preserves bioartificial liver loaded with freshly isolated liver cells

Published in Hepatitis Weekly, February 13th, 2006

Mild hypothermic preservation preserves a bioartificial liver loaded with freshly isolated liver cells.

"Preservation conditions play a crucial role during transport of a bioartificial liver (BAL) from the laboratory to the hospital. We assessed the possibility to preserve the AMC-BAL loaded with freshly isolated porcine hepatocytes at mild hypothermic temperatures," scientists in the Netherlands report.

According to P.P. Poyck and colleagues at the University of Amsterdam, "Two laboratory-scale AMC-bioreactors were loaded with I billion freshly isolated porcine hepatocytes per experiment (n=6). Bioreactors in the control group were kept for 3 days...

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