Hepatitis B Virus

Adefovir-resistant hepatitis B can be associated with viral rebound and hepatic decompensation

Published in Hepatitis Weekly, February 13th, 2006

According to recently published research from the United States, adefovir-resistant hepatitis B virus (HBV) can be associated with viral rebound and hepatic decompensation.

"The susceptibility of adefovir-resistant HBV mutants is only reduced by 3-10-fold in in vitro studies, suggesting that virologic breakthrough and clinical deterioration are unlikely. The aim of this study was to describe the clinical course of patients with adefovir-resistant HBV infection," wrote S.K. Fung and colleagues, University of Michigan.

"Testing for adefovir-resistant mutations was performed on patients who had a suboptimal response or virologic breakthrough on...

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Source: Hepatitis Weekly (2006-02-13)

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