Liver Function

Loss of function of liver retinoic acid leads to steatohepatitis and liver tumor

Published in Hepatitis Weekly, February 13th, 2006

Researchers in Japan conducted a study that reported the loss of function of retinoic acid (RA) in liver leads to steatohepatitis and liver tumor.

"To explore the role of RA in liver, we developed transgenic mice expressing retinoic acid receptor alpha dominant negative form (RARE) in hepatocytes using by albumin promoter and enhancer," wrote G. Shiota and colleagues, Tottori University.

"At 4 months of age, the RARE transgenic mice developed microvesicular steatosis and spotty focal necrosis. Mitochondrial P-oxidation activity of fatty acids and expression of its related enzymes including VLCAD, LCAD and HCD were down-regulated. On the other hand,...

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Source: Hepatitis Weekly (2006-02-13)

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