Proteomics

Retinoblastoma tumor suppressor protein is down-regulated by HCV RNA polymerase

Published in Hepatitis Weekly, February 13th, 2006

Retinoblastoma tumor suppressor protein (Rb) is down-regulated by the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.

"Rb plays a critical role in controlling cellular proliferation and apoptosis by regulating E2F transcription factors. Rb is a key target of oncoproteins expressed by DNA tumor viruses, but RNA viruses are not known to regulate Rb function."

"Here," wrote T. Munakata and colleagues, University of Texas, "we show that Rb abundance is negatively regulated in cells containing replicating genomic RNA from HCV, a human virus strongly associated with hepatocellular carcinoma."

"The viral RNA-dependent RNA...

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Source: Hepatitis Weekly (2006-02-13)

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