Steatohepatitis

Non-alcoholic steatohepatitis is modulated by pattern recognition receptors

Published in Hepatitis Weekly, February 13th, 2006

Scientists in the United States conducted a study that examined modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice.

G. Szabo and colleagues, University Massachusetts, wrote, "Toll-like receptors (TLR) recognize pathogen-derived molecules and induce downstream activation of inflammatory pathways. Fatty liver has been shown to result in increased sensitivity to lipopolysaccharide a (LPS), a TLR4 ligand."

"In this study, we investigated the roles of TLR2 and TLR4 in liver damage and on cytokine induction in a Met-Cho deficient (MCD) diet-induced model of nonalcoholic steatohepatitis."

"We found that...

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Source: Hepatitis Weekly (2006-02-13)

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