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Stem Cell Transplantation

Maximum PAI-1 plasma antigen levels not exceeding 120 ng/mL excludes VOD after HSCT

Published in Hepatitis Weekly, February 20th, 2006

Maximum plasminogen activator inhibitor-1 plasma antigen levels not exceeding 120 ng/mL excludes veno-occlusive disease following hematopoietic stem cell transplantation.

"Veno-occlusive disease (VOD) is one of the most serious complications following allogeneic hematopoietic stem cell transplantation (HSCT) and is associated with a high mortality.

"We conducted a large trial in order to investigate the value of plasminogen activator inhibitor-1 (PAI-1) plasma antigen levels in VOD patients as PAI-1 has been described as a possible diagnostic marker of VOID," researchers in Germany report.

According to M. Pihusch and colleagues at...

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