Hepatitis C Virus

HCV affects dendritic cell cytokine induction and T-cell stimulation

Published in Hepatitis Weekly, March 6th, 2006

According to recently published research from Canada, expression of hepatitis C virus (HCV)-derived core or NS3 antigens in human dendritic cells (DCs) leads to induction of pro-inflammatory cytokines and normal T-cell stimulation capabilities.

"The majority of HCV-infected individuals become chronically infected, which can result in liver cirrhosis and hepatocellular carcinoma. Patients with chronic HCV are unable to prime and maintain vigorous T-cell responses, which are required to rid the body of the viral infection."

"DCs are the professional antigen-presenting cells that probably play a dominant role in priming and maintaining vigorous T-cell...

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Source: Hepatitis Weekly (2006-03-06)

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