Hepatitis C Virus

Cell growth affects hepatitis C virus replication

Published in Hepatitis Weekly, March 20th, 2006

A study from the United States has reported on the effect of cell growth on hepatitis C virus (HCV) replication and a mechanism of cell confluence-based inhibition of HCV RNA and protein expression.

"An intimate relationship between HCV replication and the physiological state of the host liver cells has been reported. In particular, a highly reproducible and reversible inhibitory effect of high cell density on HCV replication was observed: high levels of HCV RNA and protein can be detected in actively growing cells but decline sharply when the replicon cells reach confluence."

"Arrested cell growth of confluent cells has been proposed to be...

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Source: Hepatitis Weekly (2006-03-20)

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