Published in Hepatitis Weekly, March 20th, 2006
"During thymic education, strongly self-reactive T cells are selected against, while weakly self-reactive cells are positively selected. However, the probability of an antigen being self derived and the number of self-peptides have never been properly defined," wrote Y. Louzoun and colleagues, Bar Ilan University.
They explained, "We merge algorithms for cleavage prediction, TAP binding probability estimates and MHC binding properties to estimate the number and distribution of all MHC binding peptides. We show that the number of self-peptides...
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