Hepatitis B Virus

Chronic hepatitis B virus replication utilizes covalently closed circular DNA

Published in Hepatitis Weekly, April 3rd, 2006

According to a study from Japan, chronic hepatitis B virus (HBV) replication utilizes covalently closed circular DNA (cccDNA).

"The lack of small animal models supporting chronic HBV infection impedes the assessment of anti-viral drugs in the whole animal. Although transgenic mice have been used for this purpose, these models are clearly different from natural infection, because HBV is produced from the integrated HBV sequence harbored in all hepatocytes," wrote T. Takehara and colleagues, Osaka University.

"Balb/cA nude mice were hydrodynamically injected with a plasmid having 1.5-fold over-length of HBV DNA and analyzed for HBV replication....

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Source: Hepatitis Weekly (2006-04-03)

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