Published in Hepatitis Weekly, April 3rd, 2006
"HCV envelope proteins mediate the entry of virus into cells by binding to cellular receptors, resulting in fusion of the viral membrane with the host cell membrane and permitting the viral genome to enter the cytoplasm. We report the development of a robust and reproducible cell-cell fusion assay using envelope proteins from commonly occurring genotypes of HCV," wrote M. Kobayashi and colleagues, Columbia University. "The assay scored HCV envelope protein-mediated fusion by the production of fluorescent...
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