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Hepatitis C Virus

Hepatitis C virus envelope functionally analyzed by cell-cell fusion assay

Published in Hepatitis Weekly, April 3rd, 2006

According to recently published research from the United States, a cell-cell fusion assay permits functional analysis of hepatitis C virus (HCV) envelope proteins.

"HCV envelope proteins mediate the entry of virus into cells by binding to cellular receptors, resulting in fusion of the viral membrane with the host cell membrane and permitting the viral genome to enter the cytoplasm. We report the development of a robust and reproducible cell-cell fusion assay using envelope proteins from commonly occurring genotypes of HCV," wrote M. Kobayashi and colleagues, Columbia University. "The assay scored HCV envelope protein-mediated fusion by the production of fluorescent...

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