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Hepatitis C Virus

Novel HCV vector overcomes anti-Ad5 immunity and induces immune responses

Published in Hepatitis Weekly, April 3rd, 2006

According to a study from Italy, a novel adenovirus type 6 (Ad6)-based hepatitis C virus (HCV) vector overcomes preexisting anti-Ad5 immunity and induces potent and broad cellular immune responses in rhesus macaques.

"Success in resolving HCV infection has been correlated to vigorous, multispecific, and sustained CD8+ T-cell response in humans and chimpanzees.

"The efficacy of inducing T-cell-mediated immunity by recombinant serotype 5 adenovirus vector has been proven in many animal models of infectious diseases, but its immunogenicity can be negatively influenced by preexisting immunity against the vector itself," wrote S. Capone and colleagues,...

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