Published in Hepatitis Weekly, May 15th, 2006
"HBV cccDNA, the replicative intermediate responsible for persistent HBV infection of hepatocytes, is the template for transcription of all viral mRNAs. Nuclear cccDNA accumulates as a stable episome organized into minichromosomes by histone and nonhistone proteins," wrote T. Pollicino and colleagues, University Roma La Sapienza. "In this study we investigated, by a newly developed sensitive and specific assay, the relationship between viral replication and HBV chromatin...
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