Published in Hepatitis Weekly, May 15th, 2006
"Mutations were introduced into the NS3 helicase region of a HCV Con1 subgenomic replicon to ascertain the role of the helicase in viral replication. One new replicon lacked two-thirds of the NS3 helicase (Delta hel), and six others contained one of the following six amino acid substitutions in NS3: R393A, F438A, T4501, E493K, W501A, and W501F," wrote A.M.I. Lam and colleagues, New York Medical...
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