Hepatitis B Virus
HBV surface antigen partial delipidation improves T cell antigenicity
Published in Hepatitis Weekly, May 15th, 2006
"HBsAg is a complex macromolecular particle composed of glycoproteins and lipids. The latter, representing 25% of the particle mass, are of host origin and determine the solubility, stability, and, indirectly, B-cell immunogenicity of HBsAg," wrote I. Desombere and colleagues, State University of Ghent Hospital.
They continued, "HBsAg is a T-cell-dependent immunogen that does not elicit a detectable humoral immune response in 5% of HBsAg vaccine recipients and in most subjects suffering from chronic...
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Source: Hepatitis Weekly (2006-05-15)
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