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Hepatitis B Virus

Hepatitis B and delta virus share common hepatocyte entry step

Published in Hepatitis Weekly, May 22nd, 2006

A recent study from Germany has reported that hepatitis B virus (HBV) and hepatitis delta virus (DV) share a common hepatocyte entry step.

"Insights into the early infection events of the human HBV and HDV have been limited because of the lack of a cell culture system supporting the full replication cycle for these important pathogens. The human hepatoma cell line HepaRG allows the experimental induction of a differentiated state, thereby gaining susceptibility toward HBV and HDV infection," wrote M. Engelke and colleagues, University of Heidelberg.

"We recently identified HBV envelope protein-derived lipopeptides comprising amino acids 2 though 48...

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